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Figure 4 | Cell Communication and Signaling

Figure 4

From: Platelet-derived growth factor regulates the secretion of extracellular vesicles by adipose mesenchymal stem cells and enhances their angiogenic potential

Figure 4

b-EVs and PDGF-EVs stimulate angiogenesis in vivo . A-C: representative Matrigel sections stained by trichrome method. Erythrocyte-contained vessels are indicated by arrows; A: spontaneous vessel formation in control Matrigel plug, containing non-stimulated HMEC; B: vessel formation in Matrigel plug, containing HMEC stimulated with b-EVs; C: vessel formation in Matrigel plug, containing HMEC stimulated with PDGF-EVs; D: quantitative analysis of vessel formation counted in 10 sections of Matrigel at ×20 magnification per each experimental condition; (mean ± SEM, * - p < 0,05 vs. “-control”, # - p < 0,05 vs. “b-EVs”, n = 5).

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