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Table 1 GSEA analysis: gene sets significantly correlated with MAT-inducing treatments

From: Mesenchymal to amoeboid transition is associated with stem-like features of melanoma cells

Biological category Gene set Size NES FDR (q-value) Enriched in
EGF signalling NAGASHIMA_EGF_SIGNALING_UP 57 2.773 0.000 Treated
NAGASHIMA_NRG1_SIGNALING_UP 169 2.826 0.000 Treated
ZWANG_CLASS1_TRANSIENTLY_INDUCED_BY_EGF 497 2.455 0.000 Treated
AMIT_EGF_RESPONSE_60_HELA 43 2.305 0.000 Treated
ZWANG_CLASS3_TRANSIENTLY_INDUCED_BY_EGF 217 2.263 0.000 Treated
AMIT_EGF_RESPONSE_240_HELA 59 2.177 0.001 Treated
AMIT_EGF_RESPONSE_120_HELA 67 2.098 0.002 Treated
AMIT_EGF_RESPONSE_480_MCF10A 42 2.034 0.004 Treated
AMIT_EGF_RESPONSE_40_HELA 42 1.972 0.007 Treated
Epithelial-mesenchymal transition ANASTASSIOU_CANCER_MESENCHYMAL_TRANSITION_SIGNATURE 63 -2.348 0.000 Control
AIGNER_ZEB1_TARGETS 34 -2.148 0.002 Control
ONDER_CDH1_TARGETS_1_DN 166 2.339 0.000 Treated
KARLSSON_TGFB1_TARGETS_UP 124 2.426 0.000 Treated
PLASARI_TGFB1_TARGETS_1HR_UP 34 2.296 0.000 Treated
Extracellular matrix REACTOME_COLLAGEN_FORMATION 57 -2.547 0.000 Control
PROTEINACEOUS_EXTRACELLULAR_MATRIX 95 -2.224 0.001 Control
KEGG_ECM_RECEPTOR_INTERACTION 84 -2.264 0.001 Control
PID_INTEGRIN1_PATHWAY 66 -2.200 0.001 Control
EXTRACELLULAR_MATRIX_PART 54 -2.203 0.001 Control
KEGG_CELL_ADHESION_MOLECULES_CAMS 130 -2.127 0.002 Control
EXTRACELLULAR_MATRIX 96 -2.108 0.002 Control
REACTOME_EXTRACELL_MATRIX_ORGANIZATION 83 -2.063 0.004 Control
COLLAGEN 22 -1.994 0.007 Control
HOXA5 pathway CHEN_HOXA5_TARGETS_9HR_UP 216 3.745 0.000 Treated
HDAC SENESE_HDAC1_AND_HDAC2_TARGETS_UP 227 2.790 0.000 Treated
SENESE_HDAC1_TARGETS_UP 429 2.968 0.000 Treated
SENESE_HDAC2_TARGETS_UP 110 2.525 0.000 Treated
SENESE_HDAC3_TARGETS_UP 471 2.281 0.000 Treated
Stemness NGUYEN_NOTCH1_TARGETS_DN 85 2.258 0.000 Treated
RAMALHO_STEMNESS_UP 201 2.089 0.002 Treated
Rho metabolic process BERENJENO_TRANSFORMED_BY_RHOA_DN 381 -1.951 0.010 Control
CELLULAR_PROTEIN_CATABOLIC_PROCESS 56 2.164 0.001 Treated
REACTOME_DEADENYLATION_OF_MRNA 19 2.062 0.003 Treated
PROTEIN_CATABOLIC_PROCESS 64 2.058 0.003 Treated
MRNA_METABOLIC_PROCESS 83 1.940 0.009 Treated
OXIDOREDUCTASE_ACTIVITY 281 -2.123 0.002 Control
OXIDOREDUCTASE_ACTIVITY_GO_0016616 56 -1.991 0.007 Control
OXIDOREDUCTASE_ACTIVITY_ACTING_ON_CH_OH_GROUP_OF_DONORS 62 -1.951 0.010 Control
Metastasis CHANDRAN_METASTASIS_UP 197 1.975 0.007 Treated
  CHANDRAN_METASTASIS_TOP50_UP 37 1.967 0.007 Treated
  PEDERSEN_METASTASIS_BY_ERBB2_ISOFORM_1 45 2.300 0.000 Treated