Table 1 Liver parameters and serum activities of male and female SAC-WT and SAC-KO mice
From: Hepatic Hedgehog signaling contributes to the regulation of IGF1 and IGFBP1 serum levels
Male mice | SAC-WT | n | SAC-KO | n | p value (MWU-test) |
|---|---|---|---|---|---|
Liver weight (g) | 1.65 ± 0.09 | 6 | 0.95 ± 0.03 | 14 | 0.001** |
Liver-body-weight ratio (%) | 5.58 ± 0.16 | 6 | 4.38 ± 0.14 | 14 | 0.001** |
ALAT (μkat/l) | 1.64 ± 0.48 | 3 | 2.47 ± 0.37 | 4 | 0.228 |
ASAT (μkat/l) | 8.07 ± 3.97 | 3 | 6.82 ± 1.83 | 4 | 1.000 |
GLDH (μkat/l) | 0.35 ± 0.08 | 3 | 1.93 ± 0.58 | 4 | 0.057 |
Insulin (pmol/l) | 160.53 ± 43.84 | 7 | 44.86 ± 11.97 | 5 | 0.0101* |
Glucose (mMol/dl) | 8.12 ± 0.48 | 5 | 7.22 ± 0.40 | 7 | 0.34 |
Female mice | |||||
Liver weight (g) | 1.29 ± 0.06 | 17 | 1.10 ± 0.06 | 8 | 0.724 |
Liver-body-weight ratio (%) | 5.82 ± 0.18 | 17 | 4.91 ± 0.16 | 8 | 0.001** |
ALAT (μkat/l) | 1.48 ± 0.50 | 6 | 2.47 ± 0.37 | 6 | 0.228 |
ASAT (μkat/l) | 4.80 ± 0.44 | 6 | 7.07 ± 1.10 | 6 | 1.000 |
GLDH (μkat/l) | 0.54 ± 0.10 | 6 | 1.04 ± 0.28 | 6 | 0.057 |
Insulin (pmol/l) | 98.24 ± 10.68 | 10 | 56.73 ± 5.89 | 8 | 0.0021** |
Glucose (mMol/dl) | 7.19 ± 0.24 | 9 | 6.22 ± 0.40 | 10 | 0.079 |