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Table 1 Characteristics of PDGF receptor kinase inhibitors

From: Targeting the PDGF signaling pathway in tumor treatment

Inhibitor Primary targets Secondary targets
Imatinib Abl, PDGFR, Kit Raf
Sunitinib PDGFR, VEGFR, Kit, Flt3  
Sorafenib Raf, VEGFR, PDGFR, Kit, Flt3 FGFR
Pazopanib VEGFR, PDGFR, Kit FGFR
Nilotinib Kit, Abl, PDGFR  
Cediranib VEGFR, Kit, PDGFR FGFR
Motesanib VEGFR, Kit PDGFR, Ret
Axitinib VEGFR PDGFR, Kit
Linifenib VEGFR, Kit PDGFR
Dasatinib Abl, Src PDGFR, Kit
Quizartinib FLT3 Kit, PDGFR, Ret, CSF1R
Ponatinib Ret, Abl PDGFR, VEGFR
  1. The table summarizes the specificities of some kinase inhibitors targeting PDGF receptors. The Kd:s of the different members of the PDGFR, VEGFR and FGFR families are often similar and are lumped together, for simplicity. As primary targets are listed the kinases that are inhibited at the lowest concentrations (regardless of absolute concentrations). As secondary targets are listed kinases that are inhibited by about 10-fold higher inhibitor concentrations. For references, see[3, 5054].