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Table 1 Characteristics of PDGF receptor kinase inhibitors

From: Targeting the PDGF signaling pathway in tumor treatment

Inhibitor

Primary targets

Secondary targets

Imatinib

Abl, PDGFR, Kit

Raf

Sunitinib

PDGFR, VEGFR, Kit, Flt3

 

Sorafenib

Raf, VEGFR, PDGFR, Kit, Flt3

FGFR

Pazopanib

VEGFR, PDGFR, Kit

FGFR

Nilotinib

Kit, Abl, PDGFR

 

Cediranib

VEGFR, Kit, PDGFR

FGFR

Motesanib

VEGFR, Kit

PDGFR, Ret

Axitinib

VEGFR

PDGFR, Kit

Linifenib

VEGFR, Kit

PDGFR

Dasatinib

Abl, Src

PDGFR, Kit

Quizartinib

FLT3

Kit, PDGFR, Ret, CSF1R

Ponatinib

Ret, Abl

PDGFR, VEGFR

  1. The table summarizes the specificities of some kinase inhibitors targeting PDGF receptors. The Kd:s of the different members of the PDGFR, VEGFR and FGFR families are often similar and are lumped together, for simplicity. As primary targets are listed the kinases that are inhibited at the lowest concentrations (regardless of absolute concentrations). As secondary targets are listed kinases that are inhibited by about 10-fold higher inhibitor concentrations. For references, see[3, 50–54].