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Figure 6 | Cell Communication and Signaling

Figure 6

From: Spatial and temporal aspects and the interplay of Grb14 and protein tyrosine phosphatase-1B on the insulin receptor phosphorylation

Figure 6

Activation of IR signaling in the retinal neurons. IR is inactivated through dephosphorylation by PTP1B and a direct inhibition of IR kinase activity by Grb14 (A). Src kinase phosphorylates Grb14 (B), which triggers the affinity switch from IR towards PTP1B, where it binds and directly inhibits the phosphatase activity (D). The IR, free from Grb14 and PTP1B, thus regulates the downstream neuron survival pathway (C). IR, insulin receptor; PTP1B, protein tyrosine phosphatase 1B; Grb14, growth factor receptor-bound protein 14; P, phosphorylation; Pi, inorganic phosphate.

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Cell Communication and Signaling

ISSN: 1478-811X