Table 2 An ovsssserview of the effects of the inhibitors of Ca 2+ channels on CAM-mediated neurite outgrowth
From: Cell adhesion and intracellular calcium signaling in neurons
CAMs | Cell types | Inhibitors (type of Ca2+channels) | Impact on CAM-mediated neurite outgrowth | References |
|---|---|---|---|---|
IgSF | Â | Â | Â | Â |
NCAM | PC12 cells | Diltiazem (L-type VDCCs), ω-conotoxin (N-type VDCCs) | Partial inhibition | [64] |
|  |  | Mixture of diltiazem and ω-conotoxin (L-type and N-type VDCCs) | Full inhibition | [64] |
| Â | Rat hippocampal neurons | Nifedipine, Diltiazem (L-type VDCC) | Partial inhibition | |
|  | Rat hippocampal neurons | ω-conotoxin (N-type VDCCs) | Partial inhibition | |
|  | Rat hippocampal neurons | Mixture of diltiazem and ω-conotoxin | Full inhibition | [65] |
(L-type and N-type VDCCs) | ||||
|  | Rat hippocampal neurons | ω-agatoxin (P/Q-type VDCCs) | Partial inhibition | [22] |
| Â | Rat hippocampal neurons | Mibefradil or pimozide (T-type VDCCs) | Full inhibition | [23] |
|  | Rat hippocampal neurons | ω-conotoxin (N-type VDCCs) | No inhibition | [23] |
| Â | Rat hippocampal neurons | Loe908 or SKF-96365 (NSCCs) | Full inhibition | [23] |
L1-CAM | PC12 cells | Verapamil, diltiazem, nifedipine or ω-conotoxin (L-type or N-type VDCCs) | Partial inhibition | [67] |
| Â | PC12 cells | Mixture of L-type and N-type VDCCs inhibitors | Full inhibition | [67] |
|  | Rat dorsal root ganglion neurons | ω-conotoxin or verapamil (N-type or L-type VDCCs inhibitors) | Full inhibition | [31] |
|  | Rat cerebellar neurons | Verapamil, diltiazem, nifedipine or ω-conotoxin (L-type or N-type VDCCs) | Partial inhibition | [67] |
| Â | Rat cerebellar neurons | Mixture of L-type and N-type VDCCs inhibitors | Full inhibition | [67] |
| Â | Mouse small cerebellar neurons | Verapamil, diltiazem, or nifedipine | Partial inhibition | [28] |
(L-type VDCCs) | ||||
CHL1 | Mouse hippocampal neurons | Nifedipine (L-type VDCCs) | Full inhibition | [33] |
| Â | Mouse hippocampal neurons | Pimozide (T-type VDCCs) | Full inhibition | [33] |
Thy-1 | PC12 cells | Diltiazem, nifedipine, verapamil or ω-conotoxin (L-type or N-type VDCCs) | Full inhibition | [68] |
LAMP | Rat hippocampal neurons | Nifedipine (L-type VDCCs) | Partial inhibition | [36] |
|  | Rat hippocampal neurons | ω-conotoxin (N-type VDCCs) | No inhibition | [36] |
N-cadherin | PC12 cells | Diltiazem (L-type VDCCs), ω-conotoxin (N-type VDCCs) | Partial inhibition | [64] |
|  | PC12 cells | Mixture of diltiazem and ω-conotoxin (L-type and N-type VDCCs) | Partial inhibition | [64] |
|  | Chick ciliary ganglion neurons | Mixture of diltiazem and ω-conotoxin (L-type and N-type VDCCs) | No inhibition | [39] |
β Integrin | Chick ciliary ganglion neurons | Mixture of diltiazem and ω-conotoxin (L-type and N-type VDCCs) | No inhibition | [39] |