Figure 9
From: The arrestin-domain containing protein AdcA is a response element to stress
A model for AdcA in the stress response. The model proposes that hyperosmolarity, as various other stresses, leads to a reorganization of the cytoskeletal network, and the consequent phosphorylation of response elements including STATc and AdcA, possibly through the activation of a membrane sensor. STATc participates to the cellular transcriptional response triggered by stress. AdcA dephosphorylation is in part dependent on STATc activity and correlates with recovery of the cells from stress. Whether AdcA phosphorylation allows the activation or the inhibition of AdcA is not known, but this phosphorylation or the following dephosphorylation may be required for a full cell recovery.