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Figure 4 | Cell Communication and Signaling

Figure 4

From: Exosomes are natural carriers of exogenous siRNA to human cells in vitro

Figure 4

RAD51 down-regulation by exosome delivered siRNA leads to dramatic decrease of viability of human cells. A, the survival of HeLa cells after RAD51 and RAD52 depletion by two ways: by direct specific siRNA chemical transfection (siRNA + LP) and by chemically loaded with siRNA exosomes (Exo + siRNA + LP + WF). The survival of the non-transfected cells was assumed as 100% (control). Error bars represent the standard error of the mean (SE) of at least three independent experiments. B, the example of clonogenic cell survival of the HeLa cells after co-culturing with ascites-derived exosomes (upper row) or HeLa exosomes (bottom row) which act as a carrier to deliver specific siRNAs to recipient cells.

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