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Figure 2 | Cell Communication and Signaling

Figure 2

From: Proteinase-activated receptors (PARs) – focus on receptor-receptor-interactions and their physiological and pathophysiological impact

Figure 2

PAR receptor crosstalk. Scheme illustrating the interaction of PARs and their crosstalk with other receptors [GPCRs: G protein-coupled receptors (AT1: angiotensin receptor subtype 1, B2 receptor: bradykinin B2 receptor, EP: prostaglandin receptor, 5HT2 receptor: serotonin receptor subtype 2; P2Y12: purinergic ADP receptor; SP1PR1: sphingosine-1-phosphate receptor 1); PAR: proteinase-activated receptor; RTKs: receptor tyrosine kinases (EGFR: epidermal growth factor receptor; FGFR: fibroblast growth factor receptor; IGFR: insulin-like growth factor receptor; Met: hepatocyte growth factor (HGF) receptor; PDGFR: platelet derived growth factor receptor; VEGFR: vascular endothelial growth factor receptor); RSTKs: receptor serine/threonine kinases (ALK: activin-like kinase); TLRs: toll-like receptors (NLRs: NOD-like receptors, nucleotide oligomerization domain receptors); NMDA receptor: N-methyl-D-aspartate receptor; P2X1 receptor: ATP-gated cation channel; TRPA1: transient receptor potential ankyrin A1; TRPV: transient receptor potential vanilloid; p23, p24A: transmembrane proteins of the early secretory pathway. PARs can form homomeric interactions (indicated by light red-light red coloured symbols) or heteromeric interactions with other PARs (light red-dark red coloured symbols).

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