Figure 4
From: A systems biology approach to suppress TNF-induced proinflammatory gene expressions
The effects of in silico KOs on the expression profiles of the 3 groups of genes. Simulated expression profiles of group I (A), group II (B), and group III (C) genes in 4 experimental conditions: wildtype (WT), IκBα KO, RIP1 KO and TAK1 complex KO for 12 hours using the modified TNFR1 model (with feedback). Predictions of RIP1 KO (orange curves) indicate suppression, but not abolishment, of all groups of gene expressions compared to wildtype (black curve).