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Figure 1 | Cell Communication and Signaling

Figure 1

From: A systems biology approach to suppress TNF-induced proinflammatory gene expressions

Figure 1

Schematic of TNFR1 signaling of cell survival/proinflammatory and apoptosis pathways. Upon TNF receptor activation, complexes I (survival pathway) and II (apoptosis) are formed. Complex I subsequently activates transcription factors, such as activator protein (AP)-1 and NF-κB through MAP kinases and IKK complex, respectively, which subsequently bind to promoter regions of genes to induce numerous proinflammatory genes.

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