Figure 8From: HIF-1α activation results in actin cytoskeleton reorganization and modulation of Rac-1 signaling in endothelial cellsSchematic summary of DMOG-induced modulation of endothelial cells morphology. Incubation of the cells with DMOG prevents PHD-dependent degradation of HIF-1α. Stabilized HIF-1α modulates gene expression, which, as shown in our studies, leads to reduced Rac-1 activity associated with alterations in cell morphology.Back to article page