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Figure 6 | Cell Communication and Signaling

Figure 6

From: The Campylobacter jejuniCiaD effector protein activates MAP kinase signaling pathways and is required for the development of disease

Figure 6

CiaD function is conserved between strains of C. jejuni and different cell types. (A) The MAP kinase docking motif of CiaD is required for IL-8 secretion from human INT 407 cells. Cells only were subtracted from all shown values. (B) The MAP kinase docking motif of CiaD is required for maximal invasion of human INT 407 cells. (C) The MAP kinase docking motif of CiaD is required for MIP-2 secretion from murine CT-26 cells. MIP-2 concentrations were quantified using an MIP-2 ELISA as described in Methods. Cells only were subtracted from all shown values. (D) The MAP kinase docking motif of CiaD is required for maximal invasion of murine CT-26 cells. The asterisks indicate a significant difference in the value versus that of the C. jejuni wild-type strain, as judged by one-way ANOVA followed by post-hoc Tukey’s analysis (P < 0.05). Error bars represent ± SEM of N = 12 samples from 3 independent experiments.

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Cell Communication and Signaling

ISSN: 1478-811X