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Figure 3 | Cell Communication and Signaling

Figure 3

From: Knockdown of the C. elegans Kinome identifies Kinases required for normal protein Homeostasis, Mitochondrial network structure, and Sarcomere structure in muscle

Figure 3

Kinases that appear to be required for normal sarcomere structure. (A) Sample images of GFP labelled sarcomeres showing normally aligned sarcomeres in control, non-RNAi treated, PJ727 animal (left) and RNAi treated animals showing sarcomere structure defects. RNAi treatments are indicated in the lower right corner. Scale bars represent 20 μm. (B) Kinases identified as required for maintenance of normal sarcomere structure in adult muscle. Indicated RNAi treatments were conducted chronically and followed up acutely and scored for loss of sarcomere organization, see materials and methods. Displayed are scoring data for each time point (n = 20-30). Green indicates sarcomeres not appreciably different from controls. Red indicates that at least 25% of scored animals displayed disrupted sarcomere structure versus controls. Dark red indicates that at least 50% of scored animals displayed disrupted sarcomere structure versus controls. (C) Kinases identified as required for normal sarcomere structure. RNAi treatments were conducted and scored as in (B) however the listed treatments produced a defect in the chronic screen but not the acute screen. – Indicates lack of data for a given time point. * Indicates a treatment was classed as producing a lack of progeny in this screen.

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