Figure 9
From: Hierarchical scaffolding of an ERK1/2 activation pathway
Model for hierarchical scaffolding by caveolin-1 and IQGAP1. (A) We suggest a model in which an upstream signaling module, associated with caveolin-1 and consisting of PKC, Ras, and C-Raf, is linked via Raf heterodimerization to a downstream signaling module, scaffolded by IQGAP1 and consisting of B-Raf, MEK and ERK. (B) Knock down of caveolin-1 prevents activation of actin-associated ERK1/2 by PKC, but does not interfere with actin association of ERK1/2. (C) Knock down of IQGAP1 disconnects ERK1/2 from actin.