Figure 3
From: Hierarchical scaffolding of an ERK1/2 activation pathway
ERK1/2 scaffold IQGAP1 mediates stimulus-specific ERK1/2 activation. Cells transfected with siRNA directed against IQGAP1 or KSR1, or with undirected control siRNA, were stimulated with DPBA or FCS, or left unstimulated. (A and B) Western blot analysis of cell lysates from (A) IQGAP1 knock down and (B) KSR1 knock down experiments. (C) Densitometric analysis of ERK1/2 activation after siRNA knock down. Significance (*) and p-values are indicated on chart; error bars represent standard errors.