Figure 6
From: Distinct dedifferentiation processes affect caveolin-1 expression in hepatocytes
Effects of TGF-β1 on caveolin-1 induction. (A) TGF-β1 treated hepatocytes display attenuated caveolin-1 protein upregulation. TGF-β1 dependent EMT induction is reflected by E-Cadherin downregulation. (B) Similar to the protein regulation, mRNA levels of caveolin-1 are less induced compared to corresponding controls (p ≤ 0.001 after 2, 3 and 4 days). (C) Knockdown of Smad4 attenuates TGF-β1 mediated caveolin-1 repression. (D) Inhibition of Src using SU6656 (15 μM) blocked intrinsic and TGF-β mediated upregulation of N-Cadherin and caveolin-1.