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Figure 7 | Cell Communication and Signaling

Figure 7

From: Mitochondrial translocation of cofilin is required for allyl isothiocyanate-mediated cell death via ROCK1/PTEN/PI3K signaling pathway

Figure 7

A proposed model for AITC-mediated mitochondrial injury and apoptosis. AITC-induced cell death in which ROCK1 activation represents the primary insult, leading in turn to PTEN activation and PI3K inactivation, resulting in PP1 and PP2A activation, and dephosphorylation of cofilin, which binds to G-actin and translocates to mitochondria, and culminating in cytochrome c release, caspases activation and apoptosis.

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