TY - JOUR AU - Wong, Aloysius AU - Gehring, Chris PY - 2013 DA - 2013/07/08 TI - The Arabidopsis thaliana proteome harbors undiscovered multi-domain molecules with functional guanylyl cyclase catalytic centers JO - Cell Communication and Signaling SP - 48 VL - 11 IS - 1 AB - Second messengers link external cues to complex physiological responses. One such messenger, 3’,5’-cyclic guanosine monophosphate (cGMP), has been shown to play a key role in many physiological responses in plants. However, in higher plants, guanylyl cyclases (GCs), enzymes that generate cGMP from guanosine-5’-triphosphate (GTP) have remained elusive until recently. GC search motifs constructed from the alignment of known GCs catalytic centers form vertebrates and lower eukaryotes have led to the identification of a number of plant GCs that have been characterized in vitro and in vivo. SN - 1478-811X UR - https://doi.org/10.1186/1478-811X-11-48 DO - 10.1186/1478-811X-11-48 ID - Wong2013 ER -