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Figure 4 | Cell Communication and Signaling

Figure 4

From: Phosphodiesterase activity is regulated by CC2D1A that is implicated in non-syndromic intellectual disability

Figure 4

Model of CC2D1A-PDE4D interactions. A. Western blot of time course forskolin induction (0, 2, 7 and 30 minutes) of wt and CC2D1A mutant (Δ) MEF cells after pre incubation with Rolipram, a specific PDE4 inhibitor, probed with anti-phospho CREB (S133) or anti-CREB. B. Schematic model of the mechanism by which CC2D1A regulates the negative feedback mediated by PDE4D.

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