Table 2 Minimal intervention sets in the EGF/NRG1 logical model (Figure 2 B)
From: Modeling approaches for qualitative and semi-quantitative analysis of cellular signaling networks
Intervention goal: ERK = 1, PI3K = 0 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Side constraints: ErbB1 = 1, ErbB2 = 1, ErbB3 = 1 | |||||||||||
EGF | NRG1 | ErbB11 | ErbB13 | ErbB23 | Grb2 | SOS | Ras | MEK | Gab1 | PIP3 | |
1 | 0 | 0 | 1 | ||||||||
2 | 0 | 0 | 1 | ||||||||
3 | 0 | 0 | 1 | ||||||||
4 | 0 | 1 | 0 | ||||||||
5 | 0 | 1 | 0 | ||||||||
6 | 0 | 0 | 1 | ||||||||
7 | 0 | 0 | 1 | ||||||||
8 | 0 | 0 | 1 | ||||||||
9 | 0 | 1 | 0 | ||||||||
10 | 0 | 1 | 0 | ||||||||