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Table 2 Minimal intervention sets in the EGF/NRG1 logical model (Figure 2 B)

From: Modeling approaches for qualitative and semi-quantitative analysis of cellular signaling networks

Intervention goal: ERK = 1, PI3K = 0
Side constraints: ErbB1 = 1, ErbB2 = 1, ErbB3 = 1
  EGF NRG1 ErbB11 ErbB13 ErbB23 Grb2 SOS Ras MEK Gab1 PIP3
1 0 0        1   
2   0 0       1   
3   0     0    1   
4   0        1 0  
5   0        1   0
6 0     0     1   
7    0   0     1   
8      0 0    1   
9      0     1 0  
10      0     1   0
  1. Shown are the computed minimal intervention sets to activate ERK and deactivate PI3K in presence of ErbB1, ErbB2, and ErbB3 (see Figure 2B). “1” means constitutive activation whereas “0” indicates a required deactivation. Interventions for species with fixed values (i.e., ErbB1, ErbB2, ErbB3) and the target species ERK and PI3K have not been considered.