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Table 1 Logical steady states in the EGF/NRG1 example model

From: Modeling approaches for qualitative and semi-quantitative analysis of cellular signaling networks

  With negative feedback Negative feedback removed
Fixed input values EGF 1 0 1 0
  NRG1a 0 1 0 1
  ErbB1 1 1 1 1
  ErbB2 1 1 1 1
  ErbB3 1 1 1 1
Computed logical steady state values ErbB11 1 1 1 1
  ErbB13 0 0 0 0
  ErbB23 0 1 0 1
  Grb2 1 1 1 1
  SOS * * 1 1
  Ras * * 1 1
  MEK * * 1 1
  ERK * * 1 1
  Gab1 * 1 1 1
  PI3K * 1 1 1
  PIP3 * 1 1 1
  Akt * 1 1 1
  1. The logical variables of the input nodes were set to the specified value and, according to the logical functions (see Figure 2B), propagated through the network. The entry * indicates that the respective steady state value could not be determined.