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Table 1 Logical steady states in the EGF/NRG1 example model

From: Modeling approaches for qualitative and semi-quantitative analysis of cellular signaling networks

 

With negative feedback

Negative feedback removed

Fixed input values

EGF

1

0

1

0

 

NRG1a

0

1

0

1

 

ErbB1

1

1

1

1

 

ErbB2

1

1

1

1

 

ErbB3

1

1

1

1

Computed logical steady state values

ErbB11

1

1

1

1

 

ErbB13

0

0

0

0

 

ErbB23

0

1

0

1

 

Grb2

1

1

1

1

 

SOS

*

*

1

1

 

Ras

*

*

1

1

 

MEK

*

*

1

1

 

ERK

*

*

1

1

 

Gab1

*

1

1

1

 

PI3K

*

1

1

1

 

PIP3

*

1

1

1

 

Akt

*

1

1

1

  1. The logical variables of the input nodes were set to the specified value and, according to the logical functions (see Figure 2B), propagated through the network. The entry * indicates that the respective steady state value could not be determined.
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Cell Communication and Signaling

ISSN: 1478-811X