Figure 3
From: Hypoxia-inducible factor (HIF) network: insights from mathematical models
Different model-based explanations for the switch-like behaviour. (A) Hypoxia causes the oxygen-dependent HIF degradation rate (Kdeg) via PHD and VHL to be lower than the oxygen-independent HIF synthesis rate (K0)[23]. (B) Hypoxia causes the oxygen-dependent HIF degradation pathway (Flux 1) via PHD and VHL to be lower than the oxygen-independent pathway (Flux 2)[26]. (C) Oxygen regulates the activity of PHD as well as the HIF nuclear export and the dissociation rates for HIF: HRE and HIF-1α/1β complexes[33].