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Table 1 Ï„ D Values for simulated experiments

From: Exploring the rate-limiting steps in visual phototransduction recovery by bottom-up kinetic modeling

Experiment

Ï„ D

Normalizedτ D

WT

1.42

1

0.3x RK UX

1.65

1.16

0.4x RK UX

1.53

1.08

2x RK OX

1.58

1.11

3x RK OX

1.55

1.09

Rec KO

1.38

0.97

4x Rec OX

1.73

1.22

0.2x RGS UX

6.86

4.83

2x RGS OX

0.83

0.58

4x RGS OX

0.60

0.42

6x RGS OX

0.53

0.37

0.4x RK/6x RGS

0.69

0.49

3x RK/0.2x RGS

7.30

5.14

  1. τD values, or the change in saturation time with logarithmically increasing stimulus intensities, for the various experiments simulated herein. Normalization is done against the wild-type value. (WT = wild-type, UX = underexpression, OX = overexpression, KO = knock-out). Only RGS mutants have significant effects on τD.
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Cell Communication and Signaling

ISSN: 1478-811X