Comparison between experimental (A; ref. ) and simulated (B) flash responses under conditions of Rec excess and a simulated Pepperberg plot (C) comparing these conditions (dashed lines, stars) to wild-type (solid line, open circles). Rec excess was achieved by Gray-Keller et al. (ref. ) via rod outer segment dialysis of the protein and was simulated as 4x Rec overexpression. Stimuli were 3, 6, 15, 29, 70, 157, 317 and 570 R* per flash per ref. . Rec overexpression results in a significant increase in saturation times compared to WT. (Panel A copyright © 1993 Cell Press).