Figure 5
From: Exploring the rate-limiting steps in visual phototransduction recovery by bottom-up kinetic modeling
Experimental (A-C; ref [27]) and simulated (D-F) flash responses (A, B, D, E) and Pepperberg plots (C, F) showing reduced sensitivity and shorter saturation times in animals lacking Rec (B, E) compared to wild-type (WT) (A, D). Note the difference in time scale is due to species differences. Simulated stimulus intensities were adapted from Makino et al. [27] (see Methods). Simulated WT stimuli were 9.44, 16.48, 34.24, 59.92, 111.2, 194.4, 403.2, 705.6 and 1352 R* per flash (D). Simulated Rec−/− stimuli were 10.24, 17.92, 37.2, 65.12, 120.8, 438.4, 768, 1472, 2584, 5360 and 9360 R* per flash (E). Eliminating Rec activity results in only a slight decrease in saturation time across a range of saturating stimulus intensities compared to the significant shift seen in the experimental results (C, F; open circles: WT; stars: Rec−/−). (Panels A-C copyright © 2004 Makino et al.).