Figure 3
From: Exploring the rate-limiting steps in visual phototransduction recovery by bottom-up kinetic modeling
Simulated responses under mutant conditions: 2.4x RK overexpression (A, C) and 2.3x RGS overexpression (B, D). Panels A and B present flash responses while C and D show the Pepperberg plots for saturating flashes (X’s: WT; open circles: RK overexpression; open squares: RGS overexpression). RGS expression results in greatly accelerated recovery, manifested in both decreased saturation time and reduced τ D , the slope of a regression line fitting the first four points. RK overexpression results in strongly decreased saturation times only for the model of Dell’Orco & Koch (2011; ref. [19]). This effect is attenuated in the present model.