A specific intracellular FAK-JNK signaling pathway represses CNTF. A) Incubation of C6 cells with inhibitors of JNK, but not p38 or ERK, for 4 hours, increases CNTF mRNA compared to vehicle controls (Ctrl). Data are means +/− SEM and are from 4 independent experiments. B) Incubation with FAK inhibitor reduced JNK activation as shown by reduced JNK phosphorylation in western blots, which are representative of 4 independent observations. Antibodies against total JNK were used as internal controls.