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Figure 6 | Cell Communication and Signaling

Figure 6

From: Platelet-derived growth factor-induced Akt phosphorylation requires mTOR/Rictor and phospholipase C-γ1, whereas S6 phosphorylation depends on mTOR/Raptor and phospholipase D

Figure 6

Schematic representation of PDGF-BB-mediated regulation of Akt and S6. Initially, PDGF-BB-mediated activation of Akt involves both mTORC2 and the PLCγ/PKC pathways. Activation of S6 downstream of mTORC1 depends on PLD activation, independent of mTORC2 and Akt signaling. Ca2+ is required for regulation of Akt and S6 activity.

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Cell Communication and Signaling

ISSN: 1478-811X