Skip to main content
Figure 3 | Cell Communication and Signaling

Figure 3

From: The 3.5 ångström X−ray structure of the human connexin26 gap junction channel is unlikely that of a fully open channel

Figure 3

Formation of salt bridges in different umbrella sampling windows. Left panels (AD) show side view representations of the calcein molecule in the channel pore; residues that interact with it are drawn in ball−and−stick style. Right panels (AD) show time−course plots of the distance between one carboxy group of calcein and the amino group of interacting residues. (A) Calcein interacts with a Met1 alone. (B) Moving along the axis of the pore, calcein is found in a favorable position to interact both with Met1 and with Lys41. (C, D) After breaking the interaction with Met1, calcein interacts only with Lys41; in this zone, salt bridges are less stable due to calcein interacting simultaneously with Lys41 residues from different protomers.

Back to article page