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Figure 2 | Cell Communication and Signaling

Figure 2

From: Implications of purinergic receptor-mediated intracellular calcium transients in neural differentiation

Figure 2

Functions of P2X and P2Y receptor subtypes in stem cell biology. P2Y1 and P2Y2 receptors regulate proliferation of pluripotent stem cells such as studied using P19 embryonal carcinoma cells as in vitro model. P2Y2 and P2Y1 receptors promote proliferation and neural differentiation of pluripotent and neural progenitor cells. P2Y2, P2X2 and P2X7 receptors participate in later differentiation and neural phenotype determination. P2X2 and P2X7 receptor expression/activity levels provide a further switch for neuronal or glial fate of P19 cell differentiation. Arrows indicate increases or decreases in receptor expression and activity levels in respective stages of differentiation [36].

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