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Figure 4 | Cell Communication and Signaling

Figure 4

From: Epstein-Barr virus LMP2A signaling in statu nascendi mimics a B cell antigen receptor-like activation signal

Figure 4

LMP2A expression activates the Erk MAP kinase cascade. DT40 cells were left untreated (lanes 1, 5 & 9) or induced to express LMP2A (lanes 6-8) or CD72/LMP2A (lanes 10-12) for the indicated times in the absence or presence of 50 M PD98059 (PD, lanes 4, 8 & 12). Parental cells served as control (MCM, lanes 1-4). Erk activation was monitored by immunoblot analysis of total cellular lysates with phospho-Erk-specific antibodies (upper panel). The membrane was sequentially re-probed with antibodies to the FLAG-tag, CD72 and Erk to demonstrate protein induction as well as equal protein loading.

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Cell Communication and Signaling

ISSN: 1478-811X