Table 3 Most prominent altered genes after in vitro interventions of human transformed germinal centre B cells investigated in gene expression profiles of primary samples of aggressive Non-Hodgkin Lymphoma

1

ID1

−2,07

ID1

−2,007

CYP26A1

−2,752

BCL6

−1,904

ID1

−1,9

2

ID4

−0,92

C3orf37

−1,432

ID4

−2,687

SOX2*

−1,805

RGS18*

−0,853

3

BNIP3

−0,79

SMAD1*

−1,182

BEST3*

−2,41

DNAJB4

−1,589

C3orf37

−0,85

4

TXNIP

−0,74

DEPTOR

−1,159

IL7R*

−2,399

ID3

−1,534

DDIT4

−0,83

5

BNIP3L

−0,72

CAB39L

−1,086

BMP7

−2,373

DDIT4

−1,514

ID3

−0,811

6

PFKFB4*

−0,71

CD83

−1,017

SOX4

−2,343

ID1

−1,493

METTL7A

−0,8

7

GPER

−0,68

METTL7A

−1,005

TNFSF8*

−2,264

RGCC

−1,239

CAB39L*

−0,799

8

PNOC

−0,67

ANKRD36BP2*

−0,983

RNF144B*

−2,213

IL7R

−1,152

TXNIP

−0,786

9

RGS18*

−0,66

ID3

−0,983

DNAJB4

−2,156

HEY2*

−1,136

BNIP3

−0,776

10

P4HA1

−0,654

ENPP3*

−0,937

ID1

−2,093

VEGFA

−1,115

ID4

−0,776

11

CCNG2

−0,635

IRF8

−0,924

BCL6

−2,037

GADD45A

−0,982

CCNG2

−0,721

12

HILPDA

−0,631

RGS18*

−0,919

RHOH

−2,005

CYTIP

−0,93

PFKFB4*

−0,709

13

ID2

−0,585

FAM167A*

−0,909

RGCC

−1,946

PCDH9

−0,914

KDM3A

−0,69

14

SAMD13*

−0,582

AICDA

−0,864

NCKAP1

−1,857

CCNG2

−0,889

HILPDA*

−0,678

15

CD24

−0,578

GPER

−0,852

IKZF1*

−1,845

TXNIP

−0,872

FAM167A*

−0,673

16

ID3

−0,564

ID4

−0,835

HEY2*

−1,761

BICD2

−0,868

PTPRC

−0,665

17

C3orf37

−0,56

PDZRN4

−0,809

PCDH9

−1,751

RGS18*

−0,861

STAT2*

−0,649

18

GPR18

−0,541

BNIP3

−0,785

SOX2*

−1,723

ANKRD37*

−0,852

SAMD13*

−0,631

19

ALDOC

−0,516

VEGFA

−0,777

MYCT1*

−1,716

TRIM8

−0,836

ENPP3*

−0,609

20

BBOX1

−0,516

TP53INP1*

−0,776

RGS18*

−1,715

KIAA0907

−0,786

SMAD1*

−0,593

21

CD83

−0,509

PTPRC

−0,77

SMAD1

−1,679

NEDD9

0,787

P4HA1

−0,593

22

POLD4

−0,494

RASSF6*

−0,767

MLLT3

−1,656

RELB

0,79

VEGFA

−0,592

23

HBP1

−0,484

CCNG2

−0,761

KIF20A

−1,631

PAPD5*

0,791

KLRC3

−0,591

24

FAM167A*

−0,476

CLEC2B

−0,74

FAM214A*

−1,612

ZNFX1*

0,794

GPER

−0,588

25

EVI2A

−0,476

BMP7

−0,735

BCL2

1,618

B3GNT2*

0,797

ZNF385B*

−0,588

26

TP53INP1*

−0,474

TLR1

−0,732

PSAT1*

1,62

HIF1A

0,814

TP53INP1*

−0,583

27

YPEL5

−0,467

SATB1

−0,731

LOC285628*

1,637

KIF26B

0,814

UBE2H*

−0,581

28

TRIM22

−0,464

BTG2

−0,726

FAIM3

1,641

MMD

0,82

TRIM22

−0,571

29

TLR1

−0,463

PCDH9

−0,725

MAP2K3

1,644

AICDA*

0,822

PIK3C2B

−0,571

30

CLEC2B

−0,463

PRKACB

−0,724

PPP1R15A

1,662

EPSTI1*

0,837

STAP1

−0,564

31

HLA-C

0,457

GPM6A

−0,721

FAM208B

1,674

RAB11FIP1

0,844

BNIP3L

−0,558

32

ACTR3*

0,46

STAT2*

−0,72

SIAH2

1,676

RAB30

0,845

MYBL1

−0,556

33

NAF1*

0,46

CLIP2

0,721

HIVEP3*

1,679

SIN3A*

0,847

GPM6A

−0,549

34

PSMD12

0,461

ARHGAP17

0,727

METRNL*

1,711

PLEK

0,854

ANKRD37*

−0,548

35

NUDT5*

0,461

CFLAR

0,74

HERPUD1

1,727

IFITM1

0,863

SPG11

−0,537

36

TESC

0,463

FYTTD1*

0,743

KLF10

1,749

PRDM2

0,885

NARF

−0,536

37

CCAR1*

0,464

HLA-DMB

0,747

LTA

1,753

DUSP10

0,888

ABCA1

−0,531

38

ANKRD33B*

0,465

MTMR10*

0,749

GPR18

1,769

FAM100B*

0,892

SEC14L1

−0,531

39

RILPL2*

0,466

HLA-F

0,754

IFRD1

1,777

FAS

0,894

IL7R

−0,522

40

PLCB1

0,467

PLEK

0,757

CD274*

1,785

IL7

0,896

H1FX

−0,52

41

NFKBIE

0,47

PPP1R9B*

0,759

SLC3A2

1,79

CD69

0,921

ASF1A

−0,511

42

DDX21

0,47

TESC

0,764

HSPA5

1,8

B4GALT1*

0,923

GLCCI1*

−0,509

43

TAPBP

0,471

IGLL1

0,765

ATF3

1,834

BCL2L1

0,924

EVI2A

−0,508

44

RBBP6

0,474

SNX20*

0,765

DENND4A

1,848

CD40

0,934

VGLL4

−0,507

45

SOGA2

0,474

CREM*

0,77

ARHGAP25

1,849

TET3*

0,951

PRKACB

−0,503

46

HINT1*

0,474

IKBKE

0,782

TOR3A

1,85

SOCS1

0,962

LRP4

−0,499

47

SRRM1

0,475

FAS

0,788

IRF2BP2*

1,868

NFKBID*

0,983

PLCXD1

−0,498

48

PHACTR4

0,475

CIITA

0,788

SLC30A1

1,886

SRSF5

0,996

CLEC2B

−0,497

49

AK3*

0,476

TAP1

0,789

TNF

1,905

MASTL*

1,011

LOC440864*

−0,494

50

KPNB1

0,477

NOTCH2NL*

0,797

CTH

1,91

TLR7

1,036

SLC44A1*

−0,493

51

GTF2H2B*

0,477

RFX5

0,806

APOBEC3B

1,928

MCL1

1,04

TSPAN11*

−0,484

52

TAF1D

0,477

FDXR

0,81

NFKB1

1,94

PIM2

1,06

BTN2A2

0,488

53

CSF2RB

0,479

NFKBIE

0,827

CD58

1,946

IER2

1,067

NFKBIE

0,493

54

MYBBP1A

0,481

MIR155HG*

0,829

NFKBIE

1,958

ZFP36L1

1,072

HLA-C

0,495

55

YY1*

0,483

LOXL2

0,829

NAB2

1,984

IFIT2*

1,072

LSS

0,502

56

FLVCR1*

0,488

HLA-B

0,831

JUND

2,024

SNX11

1,078

FDXR

0,502

57

NAA16

0,49

VAV2*

0,832

ARL4C

2,026

TAP1

1,086

KLHDC5*

0,505

58

SRRT

0,491

ZNF385C*

0,836

UPP1

2,029

JUNB

1,088

HLA-B

0,511

59

TNRC6A*

0,493

RASSF2

0,841

CDKN1A

2,033

LRRC32

1,1

CCDC28B

0,514

60

FNBP1

0,494

HLA-E

0,843

FAM100B*

2,059

NA

1,101

HLA-DMB

0,517

61

CIZ1

0,495

BIRC3

0,845

MDFIC

2,091

MARCKS

1,108

CUX2

0,519

62

TOMM40

0,495

ANKRD33B*

0,847

IER2

2,137

DUSP2

1,134

DUSP22*

0,523

63

TBC1D24*

0,498

ANXA7

0,85

DUSP10

2,144

NUDT4

1,139

RPS6KA1

0,527

64

ILF3

0,498

HVCN1*

0,85

FAM102A

2,198

CXCR5

1,155

HLA-DOA*

0,527

65

NFKB2

0,501

EPB41L4B*

0,86

RAB8B*

2,198

IER5

1,155

SYNCRIP

0,528

66

TFDP1*

0,505

PIK3CD

0,864

PTGER4

2,204

BCL3

1,16

ZNF385C*

0,533

67

ZNF385C*

0,508

LAT2

0,871

HLA-DQB1

2,206

SAMSN1

1,18

DENND4A

0,535

68

LYAR*

0,508

HCP5

0,884

ARAP2

2,214

NFKBIZ*

1,2

PDLIM3*

0,535

69

BIRC3

0,508

HLA-DOA*

0,894

SLC7A11

2,215

IL2RA

1,211

FYTTD1*

0,536

70

LRP8

0,513

SYNGR2

0,901

MIR155HG*

2,249

PARP9*

1,212

ELL2*

0,537

71

CCDC28B

0,514

ALCAM

0,905

CD69

2,278

USP18

1,229

HLA-E

0,539

72

C8orf12*

0,514

WNT5A

0,916

TSC22D3

2,287

MAP3K8

1,333

IRF2BP2*

0,539

73

HLA-B

0,519

RUNX3

0,932

RGS16

2,316

ZC3H12A

1,38

DNAJB1

0,54

74

HSP90B1

0,523

BMP2K*

0,935

ZFP36L1

2,331

NFKBIA

1,435

IGLL1

0,545

75

KLHDC5*

0,525

CTSH

0,935

TRIB3

2,354

RGS16

1,437

TFDP1*

0,558

76

RP9*

0,526

PLEKHO1

0,94

IL21R*

2,373

GADD45B

1,481

PSPC1*

0,56

77

PEA15

0,528

RPS6KA1

0,956

KLF6*

2,383

MIR155HG*

1,498

ANKRD33B*

0,562

78

MT1X

0,534

DUSP22

0,963

PHACTR1

2,423

LINC00158*

1,525

CREBZF

0,565

79

MAN1A1

0,539

IFIH1

0,991

SESN2*

2,446

PTGER4

1,563

IRF4

0,575

80

DNAJB1

0,543

OLFML2A

0,994

TNFAIP3

2,612

DTX3L*

1,58

C8orf12*

0,579

81

SOGA1*

0,554

HLA-DQB1

0,994

CD1C

2,662

CXCL10

1,616

FNBP1

0,617

82

CENPV*

0,555

COL1A1*

1,003

PLEK

2,716

TNFAIP3

1,636

ANXA7

0,641

83

ICAM1

0,567

ICAM1

1,006

FAM46C*

2,926

MX1

1,638

MT1X

0,67

84

CD58

0,568

NFKB2

1,009

CD83

2,973

STAT1

1,659

BATF

0,702

85

NCOR2

0,578

NEIL2*

1,021

DDIT3

2,977

BIRC3

1,66

CALR

0,703

86

SNHG12*

0,585

FNBP1

1,041

DUSP2

3,004

EGR2

1,69

HLA-DQA1*

0,706

87

SLC23A2

0,586

BATF

1,061

SQSTM1

3,036

NFKBIE

1,765

OLFML2A

0,714

88

OLFML2A

0,588

CCDC28B

1,066

PHLDA1

3,048

IFIT5

1,913

UMODL1*

0,716

89

LRRFIP1

0,59

MAN1A1

1,082

BHLHE40

3,141

BCL2A1

1,942

HLA-DQB1

0,723

90

DENND4A

0,599

CUX2

1,089

SLAMF7*

3,147

IRF1

1,965

IKBKE

0,723

91

IGLL1

0,614

HLA-DQA1*

1,092

CCR7

3,572

SLC30A1

1,969

NEIL2*

0,726

92

OVOS2*

0,63

DENND4A

1,101

NA*

3,693

IFIT3*

1,973

RILPL2*

0,779

93

C1orf63

0,649

HLA-DPA1

1,105

LINC00158*

3,798

IRF4

2,167

MAN1A1

0,781

94

EIF5B

0,681

RILPL2*

1,117

LY9*

4,131

IFIT1

2,186

CREM

0,795

95

RUNX3

0,702

DOCK10

1,202

EGR1*

4,232

CMPK2*

2,253

HLA-DPA1

0,816

96

NA

0,704

BTN2A2

1,254

BCL2A1

4,295

BATF

2,3

ACTR3*

0,833

97

HLA-DQB1

0,726

NA

1,262

EGR2

4,518

CD83

2,705

CD58

0,834

98

HLA-DQA1

0,731

ELL2*

1,467

SGK1

4,84

SGK1

2,798

NA

0,952

99

TCOF1

0,744

CD58

1,62

DUSP5

5,011

ICAM1

2,918

LINC00158*

0,954

100

ELL2*

0,747

LINC00158*

1,793

RGS1

5,476

IRF9

3,155

IFIT3*

1,051