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Table 2 Gene expression changes in human transformed germinal centre B cells of selected microarray results

From: Global gene expression changes of in vitro stimulated human transformed germinal centre B cells as surrogate for oncogenic pathway activation in individual aggressive B cell lymphomas

Gene symbol

log 2 FC

Suggested function or pathway

 

a-IgM

CD40L

IL21

BAFF

LPS

 

CIITA

0,79

0,81

-

-

-

Antigen presentation

HLA-B

0,32

0,83

0,26

0,57

0,51

Antigen presentation

HLA-C

0,34

0,71

0,28

0,52

0,5

Antigen presentation

HLA-DPA1

0,81

0,62

-

-

0,84

Antigen presentation

HLA-DQA1

1,54

1,13

-

0,75

0,74

Antigen presentation

HLA-DQB1

2,2

0,99

-

0,77

0,72

Antigen presentation

HLA-E

-

-

0,64

-

0,54

Antigen presentation

BCL11A

−0,82

-

−0,34

-

-

apoptosis

BCL2

1,63

-

-

-

-

apoptosis

BCL2A1

4,3

-

1,93

-

-

apoptosis

BCL2L1

0,41

-

0,89

-

-

apoptosis

BCL2L11

0,43

-

0,44

-

-

apoptosis

BCL2L12,

0,34

-

-

-

-

apoptosis

CFLAR

−0,43

0,74

0,54

0,45

-

apoptosis

FAS

0,91

0,83

0,89

-

-

apoptosis

MCL1

0,57

-

1,01

-

-

apoptosis

CD1C

2,67

-

-

-

-

Cell-cell communication, immune response

CD58

1,94

1,52

-

-

0,84

Cell-cell communication, immune response

CD86

1,16

−0,54

-

-

−0,34

Cell-cell communication, immune response

ICAM1

0,75

1,01

2,91

0,65

0,48

Cell adhesion

PECAM

−0,31

−0,56

-

-

−4,9

Cell adhesion

SLAMF1

0,47

-

-

-

-

Cell-cell communication, immune response

SLAMF3

4,14

−0,36

-

-

−0,42

Cell-cell communication, immune response

SLAMF6

−1,1

−0,48

−0,65

-

-

Cell-cell communication, immune response

SLAMF7

2,07

-

-

-

-

Cell-cell communication, immune response

DUSP10

2,17

-

0,89

-

-

Phosphatase activity, Negative regulation of MAPK

DUSP2

2,99

-

1,09

-

-

Phosphatase activity, Negative regulation of MAPK

DUSP22

0,74

0,98

-

-

0,53

Phosphatase activity, Negative regulation of MAPK

RGS1

5,5

-

-

-

-

Negative regulation of G-protein couppled receptors

CXCL10

-

0,4

1,63

-

-

chemokine

CCR7

3,6

-

0,57

-

-

Chemokine receptor

CXCR5

0,38

-

1,14

-

-

Chemokine receptor

BCL6

−2,03

−0,48

−1,94

-

-

Gene regulation, B cell differentiation

BCOR

−0,69

-

-

-

-

Gene regulation

GCET2

−0,95

−0,45

-

-

-

Gene regulation, B cell differentiation

ID1

−2,12

−2,04

−1,53

−2,1

−1,9

Gene regulation

ID2

0,74

-

-

-

-

Gene regulation

ID3

0,72

−1

−1,58

−0,56

−0,82

Gene regulation

ID4

−2,71

−0,83

−0,78

0,91

−0,79

Gene regulation

IRF4

1,53

0,46

2,14

-

0,58

Gene regulation, B cell differentiation

LMO2

1,45

-

0,53

-

-

Gene regulation, B cell differentiation

PRDM1

-

-

0,47

-

-

Gene regulation, B cell differentiation

AICD

−0,76

−0,34

0,82

  

Somatic hypermutation and class switch recombination

AXIN1

0,4

-

-

-

-

Wnt pathway

BCL9

−0,44

-

-

-

-

Wnt pathway

DVL1

−0,3

-

-

-

-

Wnt pathway

FLI1

−0,6

-

-

-

-

Wnt pathway

FRAT1

−0,37

-

-

-

-

Wnt pathway

FRAT2

−0,96

-

-

-

-

Wnt pathway

FRZB

−0,72

−0,39

-

-

-

Wnt pathway

FZD2

−0,56

−0,29

-

-

−0,28

Wnt pathway

FZD3

−0,81

-

-

-

-

Wnt pathway

FZD6

0,32

-

−0,3

-

-

Wnt pathway

Kremen2

-

0,35

-

-

-

Wnt pathway

LEF1

−0,85

-

-

-

−0,37

Gene regulation, Wnt pathway

Myc

−0,72

-

-

-

-

Gene regulation, Wnt pathway

PYGO1

1,13

-

-

-

-

Wnt pathway

RAG2

−0,55

    

VDJ-recombination

TCF7

-

0,44

-

-

-

Wnt pathway

TLE3

−0,66

−0,48

-

-

−0,35

Wnt pathway

WNT10

−1,37

-

-

-

-

Wnt pathway

WNT3

0,4

-

-

-

-

Wnt pathway

WNT5a

−0,72

0,93

-

-

-

Wnt pathway

WNT5B

-

0,5

-

-

-

Wnt pathway

  1. A specific regulation of genes encoding for proteins involved in cellular adhesion and costimulatory signalling, cell-cell communications or antigen presentation and immunomodulation, cytotoxicity, humoral immunity, autoimmunity, cell survival, lymphocyte development, and cell adhesion, chemokine pathways, apoptosis or Wnt-signaling and GC B cell reaction regulation is revealed. Data are presented as log2FC from one probe set. Additional details are found in Additional file 2: Table S1, Additional file 3: Table S2, Additional file 4: Table S3, Additional file 5: Table S4, Additional file 6: Table S5.