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Table 2 Gene expression changes in human transformed germinal centre B cells of selected microarray results

From: Global gene expression changes of in vitro stimulated human transformed germinal centre B cells as surrogate for oncogenic pathway activation in individual aggressive B cell lymphomas

Gene symbol log 2 FC Suggested function or pathway
  a-IgM CD40L IL21 BAFF LPS  
CIITA 0,79 0,81 - - - Antigen presentation
HLA-B 0,32 0,83 0,26 0,57 0,51 Antigen presentation
HLA-C 0,34 0,71 0,28 0,52 0,5 Antigen presentation
HLA-DPA1 0,81 0,62 - - 0,84 Antigen presentation
HLA-DQA1 1,54 1,13 - 0,75 0,74 Antigen presentation
HLA-DQB1 2,2 0,99 - 0,77 0,72 Antigen presentation
HLA-E - - 0,64 - 0,54 Antigen presentation
BCL11A −0,82 - −0,34 - - apoptosis
BCL2 1,63 - - - - apoptosis
BCL2A1 4,3 - 1,93 - - apoptosis
BCL2L1 0,41 - 0,89 - - apoptosis
BCL2L11 0,43 - 0,44 - - apoptosis
BCL2L12, 0,34 - - - - apoptosis
CFLAR −0,43 0,74 0,54 0,45 - apoptosis
FAS 0,91 0,83 0,89 - - apoptosis
MCL1 0,57 - 1,01 - - apoptosis
CD1C 2,67 - - - - Cell-cell communication, immune response
CD58 1,94 1,52 - - 0,84 Cell-cell communication, immune response
CD86 1,16 −0,54 - - −0,34 Cell-cell communication, immune response
ICAM1 0,75 1,01 2,91 0,65 0,48 Cell adhesion
PECAM −0,31 −0,56 - - −4,9 Cell adhesion
SLAMF1 0,47 - - - - Cell-cell communication, immune response
SLAMF3 4,14 −0,36 - - −0,42 Cell-cell communication, immune response
SLAMF6 −1,1 −0,48 −0,65 - - Cell-cell communication, immune response
SLAMF7 2,07 - - - - Cell-cell communication, immune response
DUSP10 2,17 - 0,89 - - Phosphatase activity, Negative regulation of MAPK
DUSP2 2,99 - 1,09 - - Phosphatase activity, Negative regulation of MAPK
DUSP22 0,74 0,98 - - 0,53 Phosphatase activity, Negative regulation of MAPK
RGS1 5,5 - - - - Negative regulation of G-protein couppled receptors
CXCL10 - 0,4 1,63 - - chemokine
CCR7 3,6 - 0,57 - - Chemokine receptor
CXCR5 0,38 - 1,14 - - Chemokine receptor
BCL6 −2,03 −0,48 −1,94 - - Gene regulation, B cell differentiation
BCOR −0,69 - - - - Gene regulation
GCET2 −0,95 −0,45 - - - Gene regulation, B cell differentiation
ID1 −2,12 −2,04 −1,53 −2,1 −1,9 Gene regulation
ID2 0,74 - - - - Gene regulation
ID3 0,72 −1 −1,58 −0,56 −0,82 Gene regulation
ID4 −2,71 −0,83 −0,78 0,91 −0,79 Gene regulation
IRF4 1,53 0,46 2,14 - 0,58 Gene regulation, B cell differentiation
LMO2 1,45 - 0,53 - - Gene regulation, B cell differentiation
PRDM1 - - 0,47 - - Gene regulation, B cell differentiation
AICD −0,76 −0,34 0,82    Somatic hypermutation and class switch recombination
AXIN1 0,4 - - - - Wnt pathway
BCL9 −0,44 - - - - Wnt pathway
DVL1 −0,3 - - - - Wnt pathway
FLI1 −0,6 - - - - Wnt pathway
FRAT1 −0,37 - - - - Wnt pathway
FRAT2 −0,96 - - - - Wnt pathway
FRZB −0,72 −0,39 - - - Wnt pathway
FZD2 −0,56 −0,29 - - −0,28 Wnt pathway
FZD3 −0,81 - - - - Wnt pathway
FZD6 0,32 - −0,3 - - Wnt pathway
Kremen2 - 0,35 - - - Wnt pathway
LEF1 −0,85 - - - −0,37 Gene regulation, Wnt pathway
Myc −0,72 - - - - Gene regulation, Wnt pathway
PYGO1 1,13 - - - - Wnt pathway
RAG2 −0,55      VDJ-recombination
TCF7 - 0,44 - - - Wnt pathway
TLE3 −0,66 −0,48 - - −0,35 Wnt pathway
WNT10 −1,37 - - - - Wnt pathway
WNT3 0,4 - - - - Wnt pathway
WNT5a −0,72 0,93 - - - Wnt pathway
WNT5B - 0,5 - - - Wnt pathway
  1. A specific regulation of genes encoding for proteins involved in cellular adhesion and costimulatory signalling, cell-cell communications or antigen presentation and immunomodulation, cytotoxicity, humoral immunity, autoimmunity, cell survival, lymphocyte development, and cell adhesion, chemokine pathways, apoptosis or Wnt-signaling and GC B cell reaction regulation is revealed. Data are presented as log2FC from one probe set. Additional details are found in Additional file 2: Table S1, Additional file 3: Table S2, Additional file 4: Table S3, Additional file 5: Table S4, Additional file 6: Table S5.