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Figure 5 | Cell Communication and Signaling

Figure 5

From: Global gene expression changes of in vitro stimulated human transformed germinal centre B cells as surrogate for oncogenic pathway activation in individual aggressive B cell lymphomas

Figure 5

Individual diffuse large B cell lymphomas are characterized by a specific activation of gene modules. The TOP100 most prominent responding genes upon stimulation of BL2 with αIgM, CD40L, IL21, LPS and BAFF (see also Table 1) were investigated for their expression in the gene expression profiles of two distinct datasets of primary lymphoma. (A) left panel: 175 DLBCLs [20]; right panel: 99 DLBCL cases [21]. DLBCL cases were ordered from left to right according to the similarity of gene expression to the stimulated status of BL2 cells. The Heatmaps display the expression of target genes (columns) across lymphoma samples (rows). The colour bar above the heatmaps marks mBL in red, non-mBL in green and intermediate lymphoma in yellow. The affiliation of samples to ABC/GCB DLBCL subgroups and the presence of an IG-MYC translocation in encoded in a bar on top of the map (see legend for colour coding). Relative gene expression is encoded with yellow (high expression) and blue (low expression). Additional details on statistical significant differences are summarized within Additional file 7: Figure S1.

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Cell Communication and Signaling

ISSN: 1478-811X