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Figure 3 | Cell Communication and Signaling

Figure 3

From: Global gene expression changes of in vitro stimulated human transformed germinal centre B cells as surrogate for oncogenic pathway activation in individual aggressive B cell lymphomas

Figure 3

Overlap in global gene expression of IL-21, CD40L, αIgM, BAFF and LPS affected genes. BL2 cells were stimulated and data were processed as described in the text. The overlaps of differentially expressed gene lists at both ends were compared using the “Ordered List package” [55]. Genes affected by the stimuli assigned on top of each plot are compared. The gene lists are compared in the same (blue line) or reversed order (green line). The y-axis gives the size of the overlap in the number of genes of the top n-genes (x-axis) in both gene lists. The orange line gives the expected size of a random overlap, and the vertical orange lines indicate 95% probability intervals of random overlaps. All overlaps show a high statistical significance (α < 0.005). Additional details are summarized within Additional file 10: Table S6, Additional file 11: Table S7, Additional file 12: Table S8, Additional file 13: Table S9, Additional file 14: Table S10, Additional file 15: Table S11, Additional file 16: Table S12, Additional file 17: Table S13, Additional file 18: Table S14, Additional file 19: Table S15.

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