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Figure 1 | Cell Communication and Signaling

Figure 1

From: Global gene expression changes of in vitro stimulated human transformed germinal centre B cells as surrogate for oncogenic pathway activation in individual aggressive B cell lymphomas

Figure 1

Identification of IL21, CD40L, αIgM, BAFF and LPS regulated genes in transformed human germinal centre B cells using microarrays. BL2 cell were stimulated with αIgM F(ab)2 fragments (3 hrs) (A), IL21 (2 hrs) (B), CD40L (6 hrs) (C), LPS (6 hrs) (D) and BAFF (9 hrs) (E). RNAs from these cells were used for gene expression profiling on Affymetrix HGU-133 plus 2.0 microarray chips. The heatmaps show the most highly changed gene expression (TOP100) (adj. p-value ≤ 0.05) in response to each stimulus. Each row in the heatmaps represents a gene and each column represents a microarray sample. Yellow and blue indicate high and low expression, respectively. Control probes (left column) are shown in comparison to stimulated probes (right column). Additional details are summarized within Table 3 and suppl. Tables 1–5.

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Cell Communication and Signaling

ISSN: 1478-811X