Figure 8
Model of S100a8/a9-Cxcl1-mediated neutrophil enrichment in TgS100a8a9hepmice. The S100a8/a9 protein complex is produced in the liver of TgS100a8a9hep mice and induces a specific expression of the neutrophil chemoattractant Cxcl1 in hepatocytes, which in turn leads to an increased pool of Cxcl1 protein in the serum of transgenic mice. Consequently, Cxcl1 enhances the release of neutrophils from the bone marrow and increases the number of circulating non-activated neutrophils, which also appear in distant organs such as liver.