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Figure 7 | Cell Communication and Signaling

Figure 7

From: Hepatocyte-specific S100a8 and S100a9 transgene expression in mice causes Cxcl1 induction and systemic neutrophil enrichment

Figure 7

Involvement of signaling pathways in Cxcl1 upregulation in hepatocytes. (A) Primary hepatocytes were isolated from Control and TgS100a8a9hep mice (n=2). Expression of p65, c-Jun, Stat3, p38, ERK1/2, and the corresponding phosphorylated forms was monitored by Western Blot analysis. (B) Primary hepatocytes were treated either with SB203580 or with (DMSO) for 5 h and relative expression of Cxcl1, Cxcl2, and Csf1 was determined by qRT-PCR; n=5, Mean +SD, students t-test, **p≤0.01.

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