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Figure 8 | Cell Communication and Signaling

Figure 8

From: NADPH oxidase 2-derived reactive oxygen species signal contributes to bradykinin-induced matrix metalloproteinase-9 expression and cell migration in brain astrocytes

Figure 8

Scheme of the BK-mediated signals linked to MMP-9 expression and brain astrocytic migration. Binding of BK to its specific receptors (B2R) stimulates activation of Ca2+/PKC-α/Nox2/ROS cascade. MMP-9 transcription is AP-1-dependently regulated by an ROS-dependent pathway. This signaling pathway may contribute to sustained expression of MMP-9 which is required for cell migration in brain astrocytes (RBA-1 cells).

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Cell Communication and Signaling

ISSN: 1478-811X