Figure 7

Model summarizing the trafficking and the molecular interaction of ARTD10. ARTD10 forms cytosolic bodies that are highly dynamic, in regard to both the intracellular mobility and the exchange of subunits. Moreover ARTD10 translocates into the nucleus dependent on an NLS-like domain and is rapidly exported in a CRM1 and NES controlled process. In the nucleus ARTD10 interacts with the oncoprotein MYC. The cytosolic ARTD10 bodies are ubiquitinated and interact with p62, a ubiquitin receptor associated with autophagy. The functional relevance of these bodies may be in autophagosomal processes and/or in other as yet undefined p62-dependent functions.