Table 3 Specificities obtained using Physiological Ligands
SH2 Domain | Specificity |
|---|---|
ABL1 | [pY] [D/E/S] [D/E] [P/N/D/E] |
ABL2 | [pY] [V] [N/Q] |
BLK | [pY] [D/E/Ï•] [D/E/L] [P/I] |
BRK | [pY] [D/E] [X] [D/E/Ï•] |
CRK | [D] [X] [pY] [D] [V/L] [P] [P] |
CRKL | [D] [X] [pY] [D] [Ï•] [P] [P/R] |
DAPP1 | [pY] [X] [X] [D/E/Ï•] [E] |
FER | [D/E] [D/E] [pY] [D/G] [D/E] [Ï•] |
FGR | [E] [P/D/E] [X] [pY] [D/E/G] [X] [D/E/Ï•] [Y] |
FYN | [pY] [X] [D/Ï•] [Ï•] |
GADS | [pY] [V] [N] |
GRAP | [pY] [V/E] [N] |
GRB2 | [pY] [V/E] [N] |
GRB7 | [pY] [E] [N/Y] |
HCK | [D/E] [D/P] [X] [pY] [D/E/G] [D/E/Ï•] [P/I/L] |
ITK | [pY] [Ï•] [X] [D/Ï•] |
LCK | [pY] [D/E/G] [D/E] [P/L] [P] |
LYN | [pY] [D/E/G] [D/E] [P] [P] |
MIST | [pY] [ϕ] [ζ] [ϕ] [D/E] [ϕ] |
NCK1 | [pY] [D/E] [E/L] [P/V] |
PI3K1_N | [pY] [V/D] [X] [I/M/V] |
PI3K1_C | [pY] [V/M/E] [N/T/M] [M] |
PLCG1_C | [pY] [Ï•] [X] [D/E] |
PTPN11_N | [pY] [Ï•] [X] [Ï•] [D/E] [Ï•] |
RASA1_N | [pY] [Ï•] [X] [D/Ï•] |
RASA1_C | [pY] [X] [X] [D/E/Ï•] |
SH2B | [pY] [X] [X] [D/E/Ï•] |
SH2D1B | [pY] [X] [X] [Ï•] |
SH2D2A | [pY] [E] [N/T] [D/Ï•] |
SH3BP2 | [pY] [D/E] [N] [V] |
SHB | [pY] [Ï•] [X] [Ï•] [D/E] [Ï•] |
SHD | [pY] [Ï•] [X] [Ï•] [D/E] [Ï•] |
SHE | [pY] [Ï•] [X] [Ï•] [D/E] [Ï•] |
SHF | [pY] [Ï•] [X] [Ï•] [D/E] [Ï•] |
SHC1 | [pY] [D/E/G] [D/E/Ï•] [Ï•] |
SLNK | [pY] [G/D/V] [D/T] [D/Ï•] |
SRC | [D/E] [X] [X] [pY] [D] [D/E/Ï•] [P/I] |
SYK_C | [Ï•] [pY] [V] [X] [D/E/Ï•] [D/E] |
TENC1 | [pY] [E] |
VAV1 | [pY] [V/E/L] [X] [P] |
YES | [pY] [D/E/G] [D/E/Ï•] [Ï•] |
ZAP70_N | [P] [X] [pY] [X] [X] [ψ/ϕ] |