Peptide sequence | Protein/position | Expected partner | Array positive | Affinity (KD)/relative affinity (IC50) | References | Comments and other SH2 domains bound |
---|---|---|---|---|---|---|
ATDDpYAVPPPR | p62DOK1 (Y409), similar to p130Cas (Y410) | Crk | Yes | N.A. | [87] | Crkl, Hck |
EDDGpYDVPKPP | Cbl (Y774) | Crk | Yes | N.A. | [88] | Crkl |
 |  | Hck | Yes | N.A. | Fgr, Src, Yes | |
AEDVpYDVPPPA | p130Cas (Y362) | Crk | Yes | KD = 0.545 μM | [87] | Src, Hck, Fyn |
GLDEpYDEVPMP | B3AT (Y921)* | Nck1 | Yes | KD = 0.06 μM | [91] | *Similar to the TIR10 peptide (EHIpYDEVAAD). Fer |
DDPSpYVNVQNL | ShcA (Y426) | Grb2 | Yes | KD = 23nM | Gads, Grap | |
 |  | Grb2 | Yes | KD = 53 ± 8nM | [94] |  |
ADNDpYIIPLPD | PDGFRb (Y1021) | Plcγ-N | Yes | KD = 0.65 - 2.2nM1 | [95] | 1Tandem SH2 domains of PLCG1 were tested against a tandem phospho-peptide of PDGFRβ Y1009/Y1021. |
 |  | Plcγ-C | Yes | KD = 0.65 - 2.2nM1 | Brk | |
 |  | Plcγ-C | Yes | KD = 4.1 ± 0.8 μM | [98] |  |
 |  | Vav1 | Yes | N.A. | [99] |  |
 |  | PI3K_N | No | ID50 = 45 ± 14 μM | [79] | Below Threshold |
SLTIpYAQVQKA | SLAM (Y280) | Sh2d1b | Yes | KD = 131nM | [100] |  |
HDGLpYQGLSTA | CD150 (Y142) | Shc1 | No | KD = 50 μM | [101] | Below Threshold |
STVEpYSTVVHS | gp130/IL-6 Receptor (Y759) | Ptpn11 | No | N.A. | [102] | PTPN11_N is 1.33X Mean, PTPN11_C is 2.8X Mean Brdg1, Brk, Sh2d1b |
AEPQpYEEIPIY | Middle T-antigen (Y323) | Src | Yes | KD = 0.55-0.8 μM | [19] | Blk, Brk, Fer, Fgr, Hck, Lyn, Nck1, Shc1, Yes |
 |  | Lck | Yes | KD = 1.3 ± 0.2 μM | [103] |  |
SDDDpYDDVDIP | HPK1 (Y379) | Nck1 | Yes | N.A. | [104] | Fer, SLNK (similar to BLNK and SLP76) |
TRDIpYETDpYpYR | InsR (Y1185,89,90) | Plcγ_C | Yes | N.A. | [105] | Crk, Crkl, Fer, Grb7, PI3K1_C |
EDLSpYGDVPPG | IRS-1 (Y151) | Nck1 | No | N.A. | [106] | 1.76X Mean Abl1, Blk, Fyn, Lck, Lyn, Sh2d1b, Shc1, Ship2, Slnk, Yes |
ELSNpYICMGGK | IRS-1 (Y465) | Ptpn11_N | No | IC50 = 48 ± 16 μM | [107] | Below Threshold, 0.9X Mean |
SIEEpYTEMMPA | IRS-1 (Y551) | Ptpn11_N | No | IC50 = 11 ± 1.0 μM | [107] | Below Threshold, 0.56X Mean |
GSGDpYMPMSPK2 | IRS-1 (Y612) | PI3K1_N | No | ID50 = 0.7-1.1 μM | [79] | 2Peptide Y632 (GSGDpYMPMSPK) on IRS-1 is similar to Y612 (TDDGpYMPMSPG) on IRS-1. |
DPNGpYMMMSPS | IRS-1 (Y662) | Ptpn11_N | No | IC50 = 96 ± 13 μM | [107] | Below Threshold, 0.54X Mean |
SPGEpYVNIEFG | IRS-1 (Y896) | Ptpn11_N | Yes | IC50 = 4.8 ± 1.0 μM | Abl2, Blk, Dapp1, Grb7, Itk, Mist, PI3K1_N, PI3K1_C, PTPN11_N, PLCγ_C, Rasa1_N, Rasa1_C, Sh2b, Sh2d1b, Shb, Shf, Shd, She, Syk_C, Vav1, Yes | |
 |  | Grb2 | Yes | KD = 35nM | Gads, Grap | |
APVSpYADMRTG | IRS-1 (Y1012) | Ptpn11_N | No | KD = 110 ± 23 μM | [107] | Below Threshold, 0.59X Mean |
NGLNpYIDLDLV | IRS-1 (Y1179) | Ptpn11_N | Yes3 | KD = 3.0 ± 0.60nM | 3Tandem SH2 domains of PTPN11 was used to bind to the tandem motif of IRS-1 | |
 |  | Ptpn11_N | Yes | IC50 = 1.1 ± 0.5 μM | [107] | Abl1, Ptpn11_N, Plcγ_C, Rasa1_N, Shb, Shf, Shd, She, Yes |
 |  | Fyn | No | N.A. | [46] | 0.45X Mean |
DLSApYASISFQ | IRS-1 (Y1229) | Ptpn11_N | No | IC50 = 25 ± 4.2 μM | [107] | Below Threshold, 2.78X Mean |
 |  | Ptpn11_C | No | N.A. | [108] | 1.59X Mean |
 |  | Fyn | No | N.A. | [46] | 0.48X Mean |
GGEFpYGYMTMD | IRS-2 (Y540) | Plcγ_C | Yes | N.A. | [111] | Dapp1, Grb7 |
PNGDpYLNVSPS | IRS-2 (Y766) | Grb2 | Yes | N.A. | [112] | Sh2d1b, Vav1 |
SNQEpYLDLSMP | FGFR1 (Y766) | Shb | No | N.A. | [113] | Similar peptide to Y760 of FGFR3 but has weak binding, 0.45X Mean |
 |  | Plcγ | No | N.A. | [55] | PLCγ_N – 0.52X Mean |
 |  |  |  |  |  | PLCγ_C – 0.21X Mean |
THDLYMIMREA | FGFR3 (Y724) | Sh2b | No | N.A. | [114] | 0.44X Mean |
STDEpYLDLSAP | FGFR3 (Y760) | Sh2b | No | N.A. | [114] | 0.46X Mean |
VSEEYLDLRLT | FGFR4 (754) | Plcγ | No | N.A. | [115] | SHD |
QVHTpYVNTTGV | FRS2 (Y196) | Grb2 | Yes | N.A. | [116] | Abl2, Gads, Grap, PI3K1_C |
NKLVpYENINGL | FRS2 (Y306) | Grb2 | Yes | N.A. | [116] | Grap, Grb7, Sh2d2a |
ALLNpYENLPSL | FRS2 (Y349) | Grb2 | Yes | N.A. | [116] | Abl1, Abl2, Gads, Grap, Grb2, Grb7, PI3K1_C, Sh2d2a, Sh3bp2 |
PMHNpYVNTENV | FRS2 (Y392) | Grb2 | Yes | N.A. | [116] | Gads, Grap |
RQLNpYIQVDLE | FRS2 (Y436) | Ptpn11_N | Yes | N.A. | [117] | Itk, Mist, PLCγ_C, Rasa1_N, Shb, Shd, She, Syk_C |
NPGFpYVEANPM | PLCγ1 (Y783) | Plcγ_C | No | N.A. | [118] | PLCγ_C at 1.03X mean; Zap70_N |
EQDEYDIPRHL | p130Cas (Y234) | Crk | Yes | N.A. | [87] | Brk, Crkl, Fyn, Lck, Lyn, Shc1, Yes |
PQDIYDVPPVR | P130Cas (Y249) | Crk | Yes | N.A. | [87] | Crkl, Zap70_N |
WMEDpYDYVHLQ | p130Cas (Y664) | Nck1 | Yes | N.A. | Bcar3, Brk, Crk, Crkl, Dapp1, Fer, Grb7, Matk, PI3K1_N, Rasa1_N, Rasa1_C, Sh3bp2 | |
 |  | Bmx | Yes | N.A. | [120] | Itk |
 |  | Src | No | KD = 25-46nM | 2.45X mean | |
 |  | Lck | No | N.A. | [121] | 2.03X mean |
PPALpYAEPLDS | p62DOK1 (Y296) | Rasa1_N | Yes | N.A. | [122] | Abl1, Nck1, Vav1, Zap70_N |
 |  | Rasa1_C | Yes | N.A. | [122] |  |
QDSLpYSDPLDS | p62DOK1 (Y315) | Rasa1_C | Yes | N.A. | [122] | Abl1, Blk, Crk, Lck, Lyn, Nck1, Src, Zap70_N |
EDPIpYDEPEGL | p62DOK1 (Y362) | Nck1 | Yes | N.A. | [123] | Blk, Hck, Lck, Lyn, Shc1, Src |
 |  | Abl1 | Yes | N.A. | [124] |  |
KEEGpYELPYNP | p62DOK1 (Y398) | Rasa1_C | Yes | N.A. | [123] | Abl1, Blk, Brk, Fgr, Fyn, Hck, Lck, Lyn, Nck1, Sh2d1b, Shc1, Ship2, Src, Vav1, Yes |
 |  | Rasa1_N | Yes | N.A. | [123] |  |