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Figure 5 | Cell Communication and Signaling

Figure 5

From: SRC Homology 2 Domain Binding Sites in Insulin, IGF-1 and FGF receptor mediated signaling networks reveal an extensive potential interactome

Figure 5

Tissue co-expression and microstate of the Insulin/IGF-1 system. Protein interaction microstates across different cell types and across time and space. (A) Co-expression between receptors and SH2 domains can influence the microstate of a specific tissue. (B) Phosphorylation of receptors under stimulation conditions can determine the temporal and spatial events of SH2 ligand binding within a cell. (C) Hierarchical clustering of the insulin responsive tissue expression levels for human SH2 domain-containing genes.

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