Skip to main content
Figure 4 | Cell Communication and Signaling

Figure 4

From: SRC Homology 2 Domain Binding Sites in Insulin, IGF-1 and FGF receptor mediated signaling networks reveal an extensive potential interactome

Figure 4

Specificity for physiological peptides defines functional groups of SH2 domains. (A) Grb2 SH2 domain positive peptides are highlighted and then represented as an EDSM logo. See Figure S5 for EDSM logos of all tested SH2 domains. (B) An unrooted dendrogram clusters families of SH2 domains related by similar binding patterns. A distance matrix between EDSMs was computed and used to generate an unrooted distance tree (see Figure S6). This is artistically represented as a dendrogram with general specificity information overlaid and functional classes denoted by branch color.

Back to article page