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Figure 8 | Cell Communication and Signaling

Figure 8

From: Vectorial secretion of CTGF as a cell-type specific response to LPA and TGF-β in human tubular epithelial cells

Figure 8

Uptake of extracellular CTGF from the apical side. A: Polarized hPTEC were treated with recombinant CTGF (10 ng/ml) for 15 min from the apical side. Cells were stained for E-cadherin (red) and CTGF (green). CTGF immunoreactivity was detected primarily in E-cadherin negative, proximal cells. Scale bar: 20 μm. B: Cells were treated as in A. N-cadherin positive cells (red) are shown at higher magnification. CTGF (green) is detectable in vesicular structures. Scale bar: 20 μm. C: Cells were treated as in A. Cells weakly positive for E-cadherin (red) showed CTGF (green) immunoreactivity, whereas distal cells with strong E-cadherin cell-cell contacts were negative. Arrows indicate cells positive for CTGF. Scale bar: 20 μm.

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