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Figure 5 | Cell Communication and Signaling

Figure 5

From: Vectorial secretion of CTGF as a cell-type specific response to LPA and TGF-β in human tubular epithelial cells

Figure 5

Preferential activation of Smad2/3 in polarized hPTEC of distal origin. Polarized hPTEC were treated with TGF-β for 1 h from the apical or basolateral side. E-cadherin (red) and Smad2/3 (green) were detected by immunocytochemistry. Cells negative for E-cadherin represent proximal cells. Upon activation with TGF-β, Smad2/3 was concentrated in the nuclei of proximal and distal cells, respectively. Arrows indicate nuclear Smad2/3 in proximal E-cadherin negative cells and arrow heads indicate nuclear Smad2/3 in distal weakly E-cadherin positive cells. Scale bar: 50 μm.

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Cell Communication and Signaling

ISSN: 1478-811X