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Table 2 Expression of cell cycle genes during the development of PCMOs cultured in the presence of HB-EGF or EGF

From: EGF and HB-EGF enhance the proliferation of programmable cells of monocytic origin (PCMO) through activation of MEK/ERK signaling and improve differentiation of PCMO-derived hepatocyte-like cells

 

ABL

ANAPC2

CDC2

CDK4

CDK6

Hb-EGF 10

1.40 ± 0.19a

1.74 ± 0.62

1.88 ± 0.74

1.53 ± 0.33

2.42 ± 1.10

Hb-EGF 50

1.26 ± 0.15a

1.40 ± 0.45

1.81 ± 0.77

1.56 ± 0.33

2.09 ± 0.80

Hb-EGF 100

1.48 ± 0.43

1.63 ± 0.66

2.23 ± 0.95

1.47 ± 0.27

2.35 ± 1.06

EGF 10

2.24 ± 0.18ab

1.78 ± 0.43

3.01 ± 1.05ab

1.57 ± 0.17

2.47 ± 0.96

EGF 50

1.69 ± 0.20ab

1.70 ± 0.42

1.99 ± 0.42a

1.39 ± 0.10

2.15 ± 0.87

EGF 100

1.74 ± 0.30ab

1.60 ± 0.38

2.02 ± 0.50a

1.53 ± 0.14

2.38 ± 0.93

ANOVA =

0.0033

0.0748

0.036

0.261

0.0756