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Figure 3 | Cell Communication and Signaling

Figure 3

From: EGF and HB-EGF enhance the proliferation of programmable cells of monocytic origin (PCMO) through activation of MEK/ERK signaling and improve differentiation of PCMO-derived hepatocyte-like cells

Figure 3

Regulation of Nanog and p47phoxexpression by EGF or HB-EGF in PCMOs. (A) Measurement of Nanog expression by qPCR in PCMOs treated for 4 days with the indicated concentrations (in μg/L) of HB-EGF or EGF. Data (mean ± SEM, N = 4) were normalized to the expression level of GAPDH. ANOVA: p < 0.01; a = all values of EGF and HB-EGF are significantly higher than that of the control; b = significant difference between EGF and the corresponding HB-EGF value. (B) Immunoblot analysis of p47phox in day-4 PCMOs treated with either HB-EGF or EGF at the indicated concentrations. The β-actin protein was detected as a loading control.

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