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Figure 6 | Cell Communication and Signaling

Figure 6

From: Regulation of Toll-like receptor 4-mediated immune responses through Pasteurella multocida toxin-induced G protein signalling

Figure 6

Proposed model of PMT-induced inhibition of LPS-stimulated IL-12 release. LPS stimulates the TLR4-mediated activation of the NFĸB-pathway and thereby the production of TNF-α, IL-6 and IL-12p40. PMT inhibits the production of IL-12 by Gαi-mediated inhibition of adenylate cyclase and cAMP accumulation and by Gβγ-mediated activation of PI3 kinase and JNK activation. PMT is shown with its N-terminal receptor binding domain (RBD) and C-terminal catalytic domain (CD).

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Cell Communication and Signaling

ISSN: 1478-811X